If you’ve been researching liver health and weight loss, you may have come across Reliver Pro.

The supplement is promoted around liver support, detoxification, metabolism and weight management, using a proprietary blend of eight ingredients including NAC, artichoke and several botanical extracts.

There’s a legitimate reason that kind of formula gets attention.

Your liver plays an essential role in metabolism, and liver health is closely connected with metabolic health.

But there’s a big difference between saying:

“The liver matters for metabolic health.”

and:

“Taking a liver-support supplement will make you lose weight.”

So I wanted to look past the marketing and answer the questions I’d want answered before buying Reliver Pro:

What’s actually in it?

Have the ingredients been studied in humans?

Are the doses comparable with clinical research?

And most importantly:

Is there evidence that Reliver Pro itself works?

Here’s what I found.

Reliver Pro at a Glance

What it is: A dietary supplement marketed for liver and metabolic support.

Serving: 2 capsules.

Bottle: 60 capsules / approximately 30 servings.

Proprietary blend: 800 mg total.

Advertised blend ingredients: NAC, artichoke, dandelion, chanca piedra, yarrow, jujube, beetroot and celery.

Individual ingredient amounts: Not disclosed.

Strongest ingredient evidence: Artichoke has some human clinical evidence involving liver-related outcomes. NAC has substantial biological and medical research behind it, although recent MASLD evidence is mixed.

Biggest drawback: We don’t know how much of each ingredient is actually in the 800 mg blend.

Weight-loss evidence: I haven’t found convincing clinical evidence showing that Reliver Pro itself causes meaningful weight loss.

My Quick Verdict

Reliver Pro contains some scientifically interesting ingredients—particularly artichoke and NAC—but the proprietary blend creates an important limitation.

The entire eight-ingredient formula provides 800 mg, without disclosing how that amount is divided.

That makes it impossible to determine whether Reliver Pro provides amounts comparable with those used in clinical research.

For that reason, I see Reliver Pro as an optional liver-support supplement, not a proven treatment for liver disease or a clinically established weight-loss solution.

Check the Current Reliver Pro Offer →

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What Is Reliver Pro?

Reliver Pro is a dietary supplement designed around the idea of supporting normal liver function.

According to the current product information, its proprietary blend contains:

N-acetyl-L-cysteine (NAC)
Artichoke
Dandelion
Chanca piedra
Yarrow
Jujube
Beetroot
Celery

Some of those ingredients have been investigated for potential antioxidant, metabolic or liver-related effects.

But there’s an important distinction to make immediately:

Evidence for an individual ingredient isn’t automatically evidence for Reliver Pro.

For a study on NAC or artichoke to tell us much about Reliver Pro, we’d ideally need to know whether Reliver Pro provides a comparable ingredient, preparation and dose.

And that’s where the proprietary blend becomes important.

What Does Reliver Pro’s 800 mg Proprietary Blend Mean?

Reliver Pro identifies the ingredients in its blend and tells us that the combined blend provides 800 mg per serving.

What it doesn’t tell us is how that 800 mg is divided between the eight ingredients.

For example, we don’t know whether a serving contains:

400 mg NAC + smaller amounts of seven botanicals

50 mg NAC + larger amounts of other ingredients.

Those would be very different formulas from an evidence perspective.

This doesn’t automatically mean the ingredients are ineffective or that there’s anything inherently wrong with using a proprietary blend.

But it does make the product considerably harder to evaluate scientifically.

And there’s another mathematical limitation worth noticing.

Eight ingredients have to fit inside 800 mg total.

That matters when we compare Reliver Pro with the doses used in human research.

Reliver Pro Ingredients: What Does the Research Actually Say?

Let’s look at all eight individually.

1. NAC — Interesting Science, but Reliver Pro’s Dose Is Unknown

N-acetyl-L-cysteine (NAC) is one of the ingredients that initially makes Reliver Pro interesting.

NAC helps replenish glutathione, an antioxidant involved in protecting cells against oxidative stress.

NAC also has established medical uses, including treatment of acetaminophen poisoning.

But that doesn’t mean an unknown amount of NAC in a dietary supplement will treat fatty liver disease.

A recent randomized controlled trial provides a particularly useful reality check.

Researchers gave people with metabolic dysfunction-associated steatotic liver disease (MASLD) 600 mg NAC three times daily—1,800 mg per day—for eight weeks.

Compared with placebo, NAC did not significantly improve liver fat grade, ALT, AST or lipid measurements, although researchers did observe improvements in several glucose, insulin, inflammatory and glutathione measures.

Now compare that with Reliver Pro.

NAC trial: 1,800 mg NAC/day.

Reliver Pro: 800 mg total for NAC + seven other ingredients.

Therefore, Reliver Pro cannot contain the 1,800 mg NAC dose used in that particular trial.

That doesn’t prove its NAC amount is ineffective.

It means we shouldn’t cite high-dose NAC research as though Reliver Pro provides the same intervention.

Evidence verdict: Interesting ingredient, but the undisclosed dose substantially limits what we can conclude about Reliver Pro.

2. Artichoke — One of the Better-Supported Ingredients

Artichoke is probably the ingredient I’d pay the most attention to in this formula.

A double-blind randomized controlled trial involving people with NAFLD used 600 mg of artichoke leaf extract per day for two months.

Researchers reported improvements in several liver-related measurements, including ALT and AST, compared with placebo.

A subsequent meta-analysis of five randomized trials involving 333 people with NAFLD also reported reductions in ALT and AST and improvements in several lipid measurements with artichoke leaf extract.

A broader review of clinical trials reports artichoke doses ranging approximately from 300 to 2,700 mg/day in NAFLD studies.

Another meta-analysis found larger AST effects in trials using more than 500 mg of artichoke.

Now consider Reliver Pro:

Its entire eight-ingredient proprietary blend is only 800 mg.

Therefore, we don’t know whether Reliver Pro contains anything close to the amounts of artichoke used in those trials.

In fact, if it contained 600 mg of artichoke, only 200 mg would remain for the other seven ingredients combined.

That’s possible mathematically, but we have no evidence that’s how the blend is formulated.

Evidence verdict: Some promising human evidence for artichoke extract itself; unknown Reliver Pro dose prevents direct comparison.

3. Dandelion — Lots of Tradition, Very Little Human Evidence

Dandelion is one of those ingredients where supplement marketing has gotten well ahead of human research.

It’s frequently promoted for:

Liver cleansing
Detoxification
Digestion
Fluid balance

There is interesting laboratory and animal research around dandelion and its compounds.

But the U.S. National Center for Complementary and Integrative Health says there is very little research on dandelion’s effects in humans and no compelling scientific evidence supporting it for any health condition.

A 2025 review focusing specifically on dandelion and liver health reached a similar conclusion: preclinical research is promising, but proper human clinical trials are still needed to establish efficacy, safety and appropriate dosing for liver disease.

So I wouldn’t consider dandelion evidence that Reliver Pro “detoxifies” the liver.

Evidence verdict: Interesting preclinical evidence, but inadequate human clinical evidence for liver treatment or weight loss.

4. Chanca Piedra — Traditional Liver Use Doesn’t Equal Clinical Proof

Chanca piedra—Phyllanthus niruri and related species—is another botanical with a long history of traditional use.

It’s perhaps best known by the nickname “stone breaker” because of its association with kidney-stone remedies.

It has also been investigated for liver-related, antioxidant and antiviral effects.

But again, we need to separate:

traditional use

from

clinically demonstrated outcomes.

Human evidence supporting chanca piedra specifically as a treatment for fatty liver or as a weight-loss aid remains limited, and there isn’t an established clinical dose that lets us meaningfully compare Reliver Pro’s undisclosed amount.

Evidence verdict: Traditional and preliminary research interest, but insufficient evidence to conclude that the amount in Reliver Pro improves liver disease or causes weight loss.

5. Yarrow — Primarily Preclinical Evidence

Yarrow (Achillea millefolium) has a long history in traditional herbal medicine.

Researchers have identified numerous compounds in yarrow with potentially interesting biological properties, including antioxidant and anti-inflammatory activity.

But that’s a long way from demonstrating that taking an unspecified amount of yarrow as part of Reliver Pro improves human liver function.

I couldn’t find convincing human clinical evidence establishing yarrow as a treatment for MASLD or as a meaningful weight-loss ingredient.

And because Reliver Pro doesn’t disclose the yarrow dose, there’s no way to compare its formulation with a standardized clinical intervention anyway.

Evidence verdict: Biologically interesting botanical, but insufficient human evidence for Reliver Pro’s major liver/weight-management claims.

6. Jujube — Interesting Plant, Weak Evidence for This Particular Use

Jujube has a long history as a food and traditional remedy and contains numerous bioactive plant compounds.

Laboratory and animal research has explored antioxidant, metabolic and liver-related effects of jujube and its constituents.

But again, that’s not the same thing as showing that an unspecified amount of jujube in a multi-ingredient supplement produces meaningful liver-health outcomes in humans.

I wouldn’t consider jujube one of the main evidence-based reasons to choose Reliver Pro.

Evidence verdict: Interesting preliminary research, but inadequate evidence to establish the liver or weight-loss effects claimed for the finished supplement.

7. Beetroot — Healthy Food, but That’s Not Proof of “Liver Detox”

I like beets.

They’re nutritious foods containing compounds including dietary nitrate and betalains, and beetroot has been investigated for cardiovascular, exercise and metabolic effects.

But we have to be careful with the logic here.

A food being nutritious doesn’t mean a small amount of its extract inside a proprietary supplement “detoxifies” your liver.

Those are completely different claims.

There is research interest in beetroot and metabolic health, but I haven’t found evidence that establishes the undisclosed amount in Reliver Pro as an effective treatment for fatty liver or a clinically meaningful weight-loss intervention.

Evidence verdict: Nutritionally interesting, but insufficient evidence for Reliver Pro-specific liver or weight-loss claims.

8. Celery — Another Ingredient Where the Dose Matters

Celery contains naturally occurring plant compounds and can absolutely be part of a healthy eating pattern.

You’ll also find animal and laboratory research examining celery extracts and various metabolic or antioxidant outcomes.

What I don’t see is strong human evidence establishing that an undisclosed amount of celery inside this particular proprietary blend will reduce liver fat or cause meaningful weight loss.

Eating celery as a vegetable and consuming a concentrated celery extract are also not interchangeable interventions.

Evidence verdict: Healthy food with interesting plant compounds, but limited evidence for the specific outcomes being marketed here.

Reliver Pro Ingredient Evidence at a Glance

Ingredient	Human Liver Evidence	Reliver Pro Dose Known?	My Assessment
NAC	Some human research; mixed MASLD results	❌	Interesting, but dose is a major limitation
Artichoke	Several human trials/meta-analyses	❌	Strongest ingredient case
Dandelion	Very limited	❌	Mostly preclinical
Chanca piedra	Limited for this use	❌	Preliminary/traditional
Yarrow	Very limited	❌	Mostly preclinical
Jujube	Limited for this use	❌	Preliminary
Beetroot	Some metabolic research, limited for this claim	❌	Interesting but unproven here
Celery	Limited for this use	❌	Weak product-specific evidence

The key point isn’t that all eight ingredients are useless.

It’s this:

The better-supported ingredients have been studied at specific doses, while Reliver Pro gives us only an 800 mg total blend and doesn’t disclose the individual amounts.

That’s the biggest obstacle to making a stronger evidence-based case for the formula.

Does Reliver Pro Work?

It depends what you mean by “work.”

Does it contain ingredients that have been researched?

Yes.

Artichoke and NAC are the clearest examples.

Does every ingredient have convincing human evidence for liver health?

No.

For ingredients such as dandelion, much of the liver-related evidence remains preclinical. NCCIH says there’s currently no compelling evidence supporting dandelion for any health condition.

Do we know whether Reliver Pro contains clinically comparable doses?

No.

The individual amounts aren’t disclosed.

Has Reliver Pro itself been proven in a high-quality clinical trial?

I haven’t found a published randomized controlled trial demonstrating that the finished Reliver Pro formula itself improves fatty liver disease or produces clinically meaningful weight loss.

That’s the distinction I’d keep in mind.

Does Reliver Pro Help With Weight Loss?

This is where I’d be particularly careful with the marketing.

The relationship between liver health and body weight is real.

But it isn’t as simple as:

“Your liver is clogged with toxins, so your metabolism stops burning fat.”

Metabolic dysfunction and excess body weight can contribute to fat accumulation in the liver.

For people with MASLD and overweight or obesity, sustainable weight reduction can improve liver health.

That’s quite different from proving that taking a liver supplement causes weight loss.

I haven’t found convincing evidence showing that Reliver Pro itself produces substantial weight loss.

So if you’re considering it because you expect to take two capsules and lose weight without changing anything else, I wouldn’t recommend buying it with that expectation.

Does Reliver Pro “Detox” Your Liver?

Your liver already performs detoxification functions continuously.

It processes substances and helps transform or eliminate compounds the body doesn’t need.

That’s very different from the popular idea that your liver becomes physically filled with vague “toxins” that need to be flushed out using a cleanse or supplement.

Some Reliver Pro ingredients may have antioxidant or other biological properties.

But that doesn’t demonstrate that the finished product removes unspecified toxins from the liver or “resets” metabolism.

I would interpret liver support much more cautiously than liver detox.

What I Like About Reliver Pro

It Contains Some Legitimately Interesting Ingredients

This isn’t a formula made entirely from obscure herbs.

Artichoke has multiple randomized trials behind it, while NAC is a well-studied compound with established biological and medical relevance.

The Formula Is Convenient

Two capsules are considerably easier to fit into everyday life than an elaborate juice cleanse or “detox” protocol.

The Ingredient Concept Makes Some Biological Sense

Combining antioxidant and botanical ingredients for general liver support isn’t inherently unreasonable.

The problem is establishing whether this particular combination at these unknown doses produces meaningful outcomes.

What I Don’t Like About Reliver Pro

1. Individual Ingredient Doses Aren’t Disclosed

This is my biggest criticism.

We know the blend contains 800 mg total, but not how much NAC, artichoke or any other ingredient we’re getting.

2. The 800 mg Total Makes Some Study Comparisons Difficult

One artichoke trial used 600 mg/day of artichoke extract alone. A recent NAC trial used 1,800 mg/day of NAC alone.

Reliver Pro has only 800 mg to divide among eight ingredients.

That doesn’t prove the formula can’t have an effect.

It does mean we shouldn’t imply that Reliver Pro reproduces results from those higher-dose single-ingredient trials.

3. I Haven’t Found a Clinical Trial on Reliver Pro Itself

That’s what I’d most like to see.

Not another study on artichoke.

A trial testing:

Reliver Pro vs placebo

at the marketed serving size.

4. Some Marketing Claims Go Beyond the Evidence

I wouldn’t consider claims of effortless fat loss, dramatic liver detoxification or metabolism “switching” established based on the ingredient evidence I’ve reviewed.

5. “Natural” Doesn’t Automatically Mean Risk-Free

Dietary supplements can cause side effects and interact with medications.

Herbal and dietary supplements have also been implicated in cases of liver injury, which makes careful supplement use particularly relevant when the product itself is marketed for liver health.

Reliver Pro Pros and Cons

Pros

Contains eight identifiable ingredients
Artichoke has some encouraging human liver-related evidence
NAC is scientifically well studied
Convenient capsule format
Doesn’t require a complicated cleanse routine
Some ingredients have plausible antioxidant/metabolic activity

Cons

Individual ingredient doses aren’t disclosed
Only 800 mg total for eight ingredients
Difficult to compare directly with clinical trial doses
Several ingredients rely primarily on preliminary/preclinical evidence for liver claims
I haven’t found a clinical trial of the finished Reliver Pro formula
Not clinically established as a weight-loss treatment
“Detox” language can oversimplify liver physiology

Who Might Consider Reliver Pro?

I think Reliver Pro makes the most sense for someone who:

Specifically wants an optional liver-support supplement
Understands that it’s not a treatment for liver disease
Doesn’t expect effortless weight loss
Accepts the uncertainty created by the proprietary blend
Has checked the current product label
Has discussed supplementation with a healthcare professional when appropriate

Who Should Be More Cautious?

Talk with a healthcare professional before taking Reliver Pro if you:

Have diagnosed liver disease
Have abnormal liver tests
Take prescription medications
Use multiple other supplements
Have gallbladder or bile-duct problems
Have chronic medical conditions
Are pregnant or breastfeeding
Are preparing for surgery

And if you’re experiencing symptoms that make you concerned about liver disease, don’t try to diagnose or treat the problem with a supplement.

Get appropriate medical evaluation.

Reliver Pro vs. Proven Liver-Healthy Habits

This comparison matters more than any ingredient table.

If I had to choose between taking Reliver Pro and consistently working on lifestyle factors known to matter for metabolic and liver health, I’d prioritize the fundamentals.

That includes:

A balanced dietary pattern

Regular physical activity

Sustainable weight management when appropriate

Managing blood sugar, cholesterol and other metabolic risk factors

Appropriate alcohol choices

Medical care for diagnosed liver disease

A supplement can potentially sit alongside those behaviors.

It shouldn’t replace them.

Is Reliver Pro FDA Approved?

No dietary supplement should be described as FDA-approved in the same way as an approved medication.

FDA explains that dietary supplements aren’t government-approved for safety and effectiveness before marketing in the way prescription drugs are. Manufacturers are responsible for ensuring their products meet applicable safety and labeling requirements, and FDA can take action against adulterated or misbranded supplements after they reach the market.

Claims such as “made in an FDA-registered facility” should therefore not be confused with:

“FDA has approved this supplement as safe and effective.”

Those aren’t the same thing.

Is Reliver Pro Worth It?

My answer depends on what you expect it to do.

If you’re thinking:

“I’ll take Reliver Pro, detox my liver and start rapidly losing belly fat.”

I wouldn’t buy it on that basis.

I don’t think the evidence supports that expectation.

But if you’re thinking:

“I’m interested in an optional liver-support supplement, I understand the limitations of proprietary blends, and I’m comfortable with the fact that the finished product hasn’t been clinically proven.”

Then Reliver Pro may be something you choose to investigate further.

I’d just go into the purchase knowing exactly what we don’t know:

We don’t know how the 800 mg blend is divided.

And that prevents us from determining whether its best ingredients are supplied at amounts comparable with clinical research.

View the Current Reliver Pro Offer →

Affiliate disclosure: I may earn a commission if you purchase through this link, at no additional cost to you.

Frequently Asked Questions About Reliver Pro

What are the ingredients in Reliver Pro?

The current Reliver Pro formula you’re reviewing advertises an 800 mg proprietary blend containing NAC, artichoke, dandelion, chanca piedra, yarrow, jujube, beetroot and celery.

The individual amount of each ingredient isn’t disclosed.

How much NAC is in Reliver Pro?

The product doesn’t disclose the individual NAC amount.

That’s important because NAC research uses specific doses. For example, a recent MASLD trial administered 600 mg three times daily, or 1,800 mg/day. Reliver Pro’s entire eight-ingredient blend is only 800 mg.

How much artichoke is in Reliver Pro?

The individual amount isn’t disclosed.

Clinical studies of artichoke for liver-related outcomes have used varying amounts, including 600 mg/day in one randomized controlled NAFLD trial, while a review of clinical studies reported roughly 300–2,700 mg/day in NAFLD research.

We therefore can’t determine whether Reliver Pro provides a comparable amount.

Does Reliver Pro work for fatty liver?

I wouldn’t use Reliver Pro to self-treat fatty liver disease.

Some individual ingredients—particularly artichoke—have been investigated in people with fatty liver disease. But that doesn’t establish Reliver Pro itself as an effective treatment.

If you have or suspect MASLD, appropriate medical evaluation is more important than choosing a supplement.

Does Reliver Pro cause weight loss?

I haven’t found convincing clinical evidence showing that Reliver Pro itself causes meaningful weight loss.

Liver health and metabolic health are connected, but that doesn’t establish that taking a liver-support supplement causes body-fat loss.

Does Reliver Pro detox the liver?

I wouldn’t interpret “detox” literally.

Your liver naturally processes and helps eliminate substances from the body. There isn’t evidence here demonstrating that Reliver Pro flushes unspecified toxins from the liver.

Is dandelion good for your liver?

Dandelion has interesting laboratory and animal research, but human evidence is limited.

NCCIH says very little human research exists and that there is currently no compelling scientific evidence supporting dandelion for any health condition.

Is Reliver Pro safe?

I can’t say that Reliver Pro is safe for everyone.

Safety depends on the amounts and forms of its ingredients, medications, other supplements, medical conditions and individual factors.

That’s another area where the proprietary blend makes evaluation more difficult because the individual ingredient amounts aren’t disclosed.

How do you take Reliver Pro?

The bottle information you provided recommends two capsules once daily, approximately 20–30 minutes before a meal with an 8-ounce glass of water, or according to healthcare-professional advice.

Follow the instructions on the actual bottle you receive, since formulations and directions can change.

Where can I buy Reliver Pro?

If you decide to try it after considering the evidence and limitations above, I’d use the product’s current official offer rather than an unknown third-party listing.

Check Reliver Pro’s Current Offer →

Affiliate link: I may earn a commission if you purchase through this link.

My Reliver Pro Review: The Bottom Line

After looking at all eight ingredients, I don’t think Reliver Pro is a product that should be dismissed simply because it uses botanical ingredients.

There is legitimate science worth discussing.

Artichoke has some encouraging human clinical evidence.

NAC is a well-studied compound, although recent MASLD results don’t show a clear improvement in liver fat or liver enzymes.

Other ingredients—including dandelion, chanca piedra, yarrow, jujube, beetroot and celery—have varying degrees of traditional, preclinical or metabolic research, but much weaker evidence for the specific liver and weight-loss outcomes we’re interested in.

The biggest limitation is the formulation itself:

Reliver Pro puts eight ingredients into an 800 mg proprietary blend without telling us how much of each one we’re getting.

That matters.

Human studies on artichoke have used hundreds of milligrams of artichoke extract alone, while the recent NAC study discussed above used 1,800 mg NAC per day.

So although Reliver Pro contains some worthwhile ingredients, we can’t assume it provides the same doses—or will produce the same results—as individual ingredients used in clinical trials.

My verdict

Reliver Pro is an interesting but incompletely transparent liver-support formula.

I would not consider it a proven treatment for fatty liver.

I would not consider it a proven weight-loss supplement.

And I would not buy it expecting a liver “detox” to suddenly switch on fat burning.

But for someone who understands those limitations and still wants an optional supplement containing several liver-focused ingredients, it may be worth investigating.

Check Reliver Pro Price & Current Offer →

Affiliate disclosure: If you purchase through my link, I may earn a commission at no additional cost to you.

Medical disclaimer: This article is for general informational purposes only and isn’t intended to diagnose, treat, cure or prevent disease. Dietary supplements can cause side effects and interact with medications. If you have diagnosed or suspected liver disease, abnormal liver tests, take medications, are pregnant or breastfeeding, or have questions about whether a supplement is appropriate for you, consult an appropriate healthcare professional.